Prognostic value of CT characteristics in crizotinib-treated patients with advanced non-small cell lung cancer / 中国肿瘤临床
Chinese Journal of Clinical Oncology
; (24): 568-574, 2019.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-754462
Responsible library:
WPRO
ABSTRACT
Objective:
To investigate the prognostic value of chest computed tomography (CT) characteristics in crizotinib-treated pa-tients with advanced non-small cell lung cancer (NSCLC).Methods:
Forty-seven patients with advanced ALK-rearranged NSCLC who re-ceived crizotinib treatment from January 2014 to March 2017 were enrolled in this retrospective study. Pre-treatment CT characteris-tics were evaluated. Patients were followed up after crizotinib treatment, and the best overall response and progression-free survival (PFS) were assessed according to the Response Evaluation Criteria in Solid Tumors (RECIST version 1.1).Results:
The median PFS of all patients was 10 months. There was no association between CT characteristics and response. In univariate analysis, large tumor size (P=0.009), central type (P=0.002), consolidation of surrounding lung tissue (P=0.002), pleural effusion (P=0.001), and lymphangitic carcino-matosis (P=0.019) suggested a poor prognosis. Multivariate Cox regression analysis showed that location (hazard ratio, 3.219; 95% con-fidence interval 1.517-6.833; P=0.002) was an independent prognostic predictor.Conclusions:
Pre-treatment CT characteristics are useful in predicting the PFS of crizotinib-treated patients with advanced NSCLC harboring ALK rearrangement.
Full text:
Available
Database:
WPRIM (Western Pacific)
Type of study:
Observational study
/
Prognostic study
Language:
Chinese
Journal:
Chinese Journal of Clinical Oncology
Year:
2019
Document type:
Article