Median effective dose of etomidate inducing electroencephalogram burst suppression in patients with non-intracranial diseases / 中华麻醉学杂志
Chinese Journal of Anesthesiology
; (12): 218-220, 2019.
Article
in Zh
| WPRIM
| ID: wpr-755524
Responsible library:
WPRO
ABSTRACT
Objective To determine the median effective dose (EDs0) of etomidate inducing electroencephalogram (EEG) burst suppression (BS) in the patients with non-intracranial diseases.Methods American Society of Anesthesiologists physical status Ⅰ or Ⅱ patients of both sexes,aged 18-64 yr,with body mass index of 19-27 kg/m2,scheduled for elective non-intracranial surgery,were enrolled in this study.ED50 of etomidate was determined by Dixon's up-and-down sequential method.Etomidate was intravenously injected for 30 s at an initial dose of 0.30 mg/kg.The BS ratio was recorded within 6 min following the end of injection.Each time ED50 increased/decreased in the next patient depending on whether or not BS occurred.The difference between the two successive doses was 0.05 mg/kg.Successful induction of BS was defined as BS ratio> 10%,lasting more than 1 min.Probit analysis was used to calculate the ED50 and 95% confidence interval of etomidate inducing EEG BS in the patients with non-intracranial diseases.Results The ED50 of etomidate inducing EEG BS was 0.70 mg/kg,and the 95% confidence interval was 0.65-0.81 mg/kg in the patients with non-intracranial diseases.Conclusion The ED50 of etomidate inducing EEG BS is 0.70 mg/kg in the patients with non-intracranial diseases.
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Database:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Anesthesiology
Year:
2019
Document type:
Article