Prognostic Role of Serum Vitamin B₁₂ in Solid Tumor Patients
Korean Journal of Health Promotion
; : 282-288, 2017.
Article
in Korean
| WPRIM (Western Pacific)
| ID: wpr-7566
Responsible library:
WPRO
ABSTRACT
BACKGROUND:
Serum vitamin B₁₂ has been suggested as one of the cancer diagnostic markers and predictors for survival in cancer patients. In this study, we investigated the relationship between vitamin B₁₂ and tumor progression.METHODS:
Solid tumor patients who had serum vitamin B₁₂ levels and radiologic test follow-up were included in the study. A total of 55 patients were included. Receiver operating characteristic analysis was performed to determine the cut-off value of vitamin B₁₂ for tumor progression. Kaplan-Meier method and Cox proportional hazard model for time to progression (TTP) were performed. Subgroup analysis was performed on patients with or without liver lesion (hepatocellular carcinoma and liver metastasis).RESULTS:
The cut-off value of vitamin B₁₂ for tumor progression prediction was 691.4 pg/mL, the sensitivity was 57.1% and the specificity was 59.3%. Patients with vitamin B₁₂≥691.4 pg/mL had shorter median TTP (2.1 months vs. 3.4 months, P=0.011). In subgroup analysis of patients without liver lesion, median TTP was significantly shorter in patients with vitamin B₁₂≥691.4 pg/mL (1.6 months vs. 6.3 months, P=0.021), while there was no significant difference in TTP among the patients with liver lesion. Higher vitamin B₁₂ level (≥691.4 pg/mL) was an independent prognostic factor for tumor progression (adjusted hazard ratio 2.4, 95% confidence interval 1.2–4.8, P=0.019).CONCLUSIONS:
Serum vitamin B₁₂ level can be used as a predictor of tumor progression in patients with solid tumors especially in patients without liver lesion. Additional large scale prospective studies are required to confirm this.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Vitamins
/
Biomarkers
/
Proportional Hazards Models
/
Prospective Studies
/
ROC Curve
/
Follow-Up Studies
/
Sensitivity and Specificity
/
Disease Progression
/
Liver
/
Methods
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Health Promotion
Year:
2017
Document type:
Article