Omic studies reveal the pathogenic lipid droplet proteins in non-alcoholic fatty liver disease
Protein & Cell
; (12): 4-13, 2017.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-757375
Responsible library:
WPRO
ABSTRACT
Non-alcoholic fatty liver disease (NAFLD) is an epidemic metabolic condition driven by an underlying lipid homeostasis disorder. The lipid droplet (LD), the main organelle involved in neutral lipid storage and hydrolysis, is a potential target for NAFLD therapeutic treatment. In this review, we summarize recent progress elucidating the connections between LD-associated proteins and NAFLD found by genome-wide association studies (GWAS), genomic and proteomic studies. Finally, we discuss a possible mechanism by which the protein 17β-hydroxysteroid dehydrogenase 13 (17β-HSD13) may promote the development of NAFLD.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Genomics
/
Proteomics
/
Lipid Metabolism
/
Genome-Wide Association Study
/
Lipid Droplets
/
Non-alcoholic Fatty Liver Disease
/
Genetics
/
17-Hydroxysteroid Dehydrogenases
/
Metabolism
Limits:
Animals
/
Humans
Language:
English
Journal:
Protein & Cell
Year:
2017
Document type:
Article