A versatile building block: the structures and functions of negative-sense single-stranded RNA virus nucleocapsid proteins
Protein & Cell
; (12): 893-902, 2012.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-757847
Responsible library:
WPRO
ABSTRACT
Nucleocapsid protein (NPs) of negative-sense single-stranded RNA (-ssRNA) viruses function in different stages of viral replication, transcription, and maturation. Structural investigations show that -ssRNA viruses that encode NPs preliminarily serve as structural building blocks that encapsidate and protect the viral genomic RNA and mediate the interaction between genomic RNA and RNA-dependent RNA polymerase. However, recent structural results have revealed other biological functions of -ssRNA viruses that extend our understanding of the versatile roles of virally encoded NPs.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Physiology
/
RNA Viruses
/
Chemistry
/
Capsid
/
Orthobunyavirus
/
Nucleocapsid Proteins
/
Lassa virus
/
Metabolism
Limits:
Animals
/
Humans
Language:
English
Journal:
Protein & Cell
Year:
2012
Document type:
Article