New components of the necroptotic pathway

Zhenru ZHOU; Victor HAN; Jiahuai HAN

Zhenru ZHOU; Victor HAN; Jiahuai HAN.

Protein & Cell ; (12): 811-817, 2012.

Article in English | WPRIM (Western Pacific) | ID: wpr-757853

Responsible library: WPRO

ABSTRACT

ABSTRACT

Programmed necrosis, also known as necroptosis, has recently drawn great attention. As an important cellular regulation mechanism, knowledge of its signaling components is expanding. Necroptosisis demonstrated to be regulated by the RIP1 and RIP3 kinases, and its pathophysiological importance has been confirmed in a number of disease models. Here we review the new members of this necroptosis pathway, MLKL, PGAM5, Drp1 and DAI, and discuss some of their possible applications according to recent findings.

Subject(s)

Animals; Humans; Carrier Proteins; Metabolism; DNA-Binding Proteins; Metabolism; GTP Phosphohydrolases; Metabolism; Microtubule-Associated Proteins; Metabolism; Mitochondrial Proteins; Metabolism; Necrosis; Phosphoprotein Phosphatases; Protein Kinases; Chemistry; Metabolism; Receptor-Interacting Protein Serine-Threonine Kinases; Metabolism; Signal Transduction; Tumor Necrosis Factors; Metabolism

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Full text: Available Database: WPRIM (Western Pacific) Main subject: Protein Kinases / Signal Transduction / Carrier Proteins / Chemistry / Phosphoprotein Phosphatases / Mitochondrial Proteins / Tumor Necrosis Factors / DNA-Binding Proteins / Receptor-Interacting Protein Serine-Threonine Kinases / GTP Phosphohydrolases Type of study: Prognostic study Limits: Animals / Humans Language: English Journal: Protein & Cell Year: 2012 Document type: Article

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