Effects of CYP1A enzyme specific inhibitor on pharmacokinetics of para-acetaminophen in Bactrian camel
Journal of Veterinary Science
; : e12-2019.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-758921
Responsible library:
WPRO
ABSTRACT
The effects of CYP1A enzyme on the pharmacokinetics of p-acetaminophen were studied in Bactrian camel. Twelve Bactrian camels were divided into 2 groups, then given a single dose of p-acetaminophen only or with the enzyme inhibitor lomefloxacin. Blood samples were collected after different intervals, and p-acetaminophen concentration was determined by high-performance liquid chromatography. Pharmacokinetic parameters were analyzed by Phoenix WinNonLin v.7.0. The results show that lomefloxacin can significantly inhibit Bactrian camel CYP1A enzyme, as evidenced by the prolonged elimination half-life, increased maximum plasma concentration and area under the curve values and the shortened time to peak concentration for p-acetaminophenol in the substrate with inhibitor group. The results lay a foundation for revealing the particular characteristics of the CYP1A enzyme in Bactrian camels.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Plasma
/
Camelus
/
Pharmacokinetics
/
Chromatography, Liquid
/
Half-Life
Type of study:
Prognostic study
Language:
English
Journal:
Journal of Veterinary Science
Year:
2019
Document type:
Article