Ultrasound Feature-Based Diagnostic Model Focusing on the “Submarine Sign” for Epidermal Cysts among Superficial Soft Tissue Lesions
Korean Journal of Radiology
; : 1409-1421, 2019.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-760254
Responsible library:
WPRO
ABSTRACT
OBJECTIVE:
To develop a diagnostic model for superficial soft tissue lesions to differentiate epidermal cyst (EC) from other lesions based on ultrasound (US) features. MATERIALS ANDMETHODS:
This retrospective study included 205 patients who had undergone US examinations for superficial soft tissue lesions and subsequent surgical excision. The study population was divided into the derivation set (n = 112) and validation set (n = 93) according to the imaging date. The following US features were analyzed to determine those that could discriminate EC from other lesions more-than-half-depth involvement of the dermal layer, “submarine sign” (focal projection of the hypoechoic portion to the epidermis), posterior acoustic enhancement, posterior wall enhancement, morphology, shape, echogenicity, vascularity, and perilesional fat change. Using multivariable logistic regression, a diagnostic model was constructed and visualized as a nomogram. The performance of the diagnostic model was assessed by calculating the area under the curve (AUC) of the receiver operating characteristic curve and calibration plot in both the derivation and validation sets.RESULTS:
More-than-half-depth involvement of the dermal layer (odds ratio [OR] = 3.35; p = 0.051), “submarine sign” (OR = 12.2; p < 0.001), and morphology (OR = 5.44; p = 0.002) were features that outweighed the others when diagnosing EC. The diagnostic model based on these features showed good discrimination ability in both the derivation set (AUC = 0.888, 95% confidence interval [95% CI] = 0.825–0.950) and validation set (AUC = 0.902, 95% CI = 0.832–0.972).CONCLUSION:
More-than-half-depth of involvement of the dermal layer, “submarine sign,” and morphology are relatively better US features than the others for diagnosing EC.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Acoustics
/
Calibration
/
Logistic Models
/
Retrospective Studies
/
ROC Curve
/
Ultrasonography
/
Nomograms
/
Discrimination, Psychological
/
Epidermal Cyst
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Korean Journal of Radiology
Year:
2019
Document type:
Article