Flavestin K, An Isoprenylated Stilbene from the Leaves of Macaranga recurvata Gage
Natural Product Sciences
; : 244-247, 2019.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-760565
Responsible library:
WPRO
ABSTRACT
A new isoprenylated stilbene, flavestinK (1) together with two known isoprenylated stilbenes, flavestin B (2), flavestin G (3), and two isoprenilated flavanones, 4-O-methyl-8-isoprenylnaringenin (4) and 8-isoprenyl-5,7-dihydroxyflavanone (5) were isolated from the leaves of Macaranga recurvata Gage. All of the structures have been determined based on HRESIMS, 1D and 2D NMR spectral data. All of the isolated compounds were evaluated for their cytotoxicity against three human cancer cells (HeLa, T47D and WiDr). Compound 1 showed higher activity than doxorubicin against HeLa cells with IC₅₀ value of 13.1 µg/mL.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Stilbenes
/
HeLa Cells
/
Doxorubicin
/
Euphorbiaceae
/
Flavanones
Limits:
Humans
Language:
English
Journal:
Natural Product Sciences
Year:
2019
Document type:
Article