Expression of Metabotropic Glutamate Receptors in the Medial Vestibular Nucleus Following Acute Hypotension in Rats / 대한평형의학회지
Journal of the Korean Balance Society
; : 131-137, 2012.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-761125
Responsible library:
WPRO
ABSTRACT
BACKGROUND AND OBJECTIVES:
Acute hypotension induces expression of c-Fos protein and phosphorylated extracellular signal-regulated kinase (pERK), and glutamate release in the vestibular nuclei. Expression of c-Fos protein and pERK is mediated by the excitatory neurotransmitter, glutamate. In this study, the signaling pathway of glutamate in the vestibular nuclei following acute hypotension was investigated. MATERIALS ANDMETHODS:
Expression of metabotropic glutamate receptors (mGluRs) was measured by Western blotting in the medial vestibular nucleus following acute hypotension in rats.RESULTS:
Expression of pGluR1 Ser831, a subtype of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, peaked at 30 minutes after acute hypotension insult, and expression of pNR2B, a subtype of N-methyl-D-aspartate (NMDA) receptors, peaked at 2 hours after acute hypotension insult. Acute hypotension induced expression of Homer1a and group I mGluR in the medial vestibular nucleus. Expression of mGluR1 and mGluR5 peaked at 6 hours following acute hypotension insults.CONCLUSION:
These results suggest that afferent signals from the peripheral vestibular receptors, resulting from acute hypotension insult, are transmitted through group I mGluRs as well as AMPA and NMDA receptors in the vestibular system.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Phosphotransferases
/
Vestibular Nuclei
/
Blotting, Western
/
N-Methylaspartate
/
Receptors, N-Methyl-D-Aspartate
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Receptors, Metabotropic Glutamate
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Alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
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Neurotransmitter Agents
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Glutamic Acid
/
Hypotension
Limits:
Animals
Language:
English
Journal:
Journal of the Korean Balance Society
Year:
2012
Document type:
Article