Prophylactic Antiviral Treatment in Immunosuppressed Chronic Hepatitis B Patients / 대한소화기학회지
The Korean Journal of Gastroenterology
; : 258-266, 2019.
Article
in Korean
| WPRIM (Western Pacific)
| ID: wpr-761568
Responsible library:
WPRO
ABSTRACT
Improved management of chronic hepatitis B patients with oral nucleos(t)ide analogues has increased the number of these patients who are getting older and have other accompanying comorbidities. These comorbidities frequently require various immunosuppression treatments and/or cytotoxic chemotherapy. Not only the patients who are positive for HBsAg, but also the patients who are positive for isolated anti-HBc are at risk for hepatitis B reactivation during immunosuppression. Prophylactic antiviral treatment with oral nucleos(t)ide analogues with high genetic barriers can decrease the risks of HBV reactivation, HBV reactivation-associated hepatitis, and mortality in these patients. It is crucial to screen HBV markers in all of the patients who have to undergo immunosuppression, be administered prophylactic antiviral treatment in the high risk groups, and be monitored for HBV reactivation during and after immunosuppression and/or cytotoxic chemotherapy. This study summarizes the recommendations from the recently updated guidelines from Korea, United States, and Europe.
Full text:
Available
Health context:
SDG3 - Health and Well-Being
/
SDG3 - Target 3.3 End transmission of communicable diseases
/
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
Target 3.3: End transmission of communicable diseases
/
Hepatitis
/
Digestive System Diseases
Database:
WPRIM (Western Pacific)
Main subject:
United States
/
Comorbidity
/
Mortality
/
Immunosuppression Therapy
/
Hepatitis B, Chronic
/
Drug Therapy
/
Europe
/
Hepatitis
/
Hepatitis B
/
Hepatitis B Surface Antigens
Type of study:
Practice guideline
/
Prognostic study
Limits:
Humans
Country/Region as subject:
North America
/
Asia
/
Europa
Language:
Korean
Journal:
The Korean Journal of Gastroenterology
Year:
2019
Document type:
Article