Long non-coding RNA T-cell leukemia/lymphoma 6 serves as a sponge for miR-21 modulating the cell proliferation of retinoblastoma through PTEN
The Korean Journal of Physiology and Pharmacology
; : 449-458, 2019.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-761819
Responsible library:
WPRO
ABSTRACT
Retinoblastoma (Rb) is one of the most common eye malignancies occur in childhood. The crucial roles of non-coding RNAs, particularly long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), have been widely reported in Rb progression. In the present study, we found the expression of lncRNA T-cell leukemia/lymphoma 6 (TCL6) was significantly downregulated in Rb tissues and cell lines. Knockdown of lncRNA TCL6 promoted cell proliferation while reduced cell apoptosis in Rb cells. Moreover, lncRNA TCL6 serves as a sponge for miR-21, a previously-reported oncogenic miRNA in Rb, by direct targeting to negatively regulated miR-21 expression, therefore modulating Rb proliferation through miR-21. TCL6 overexpression inhibited Rb cell proliferation while miR-21 overexpression exerted an opposing effect; the effect of TCL6 overexpression was partially attenuated by miR-21 overexpression. PTEN/PI3K/AKT signaling pathway was involved in lncRNA TCL6/miR-21 axis modulating Rb cell proliferation. Taken together, lncRNA TCL6 serves as a tumor suppressor by acting as a sponge for miR-21 to counteract miR-21-mediated PTEN repression.
Full text:
Available
Health context:
SDG3 - Health and Well-Being
/
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
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SDG3 - Target 3.2 Reduce avoidable death in newborns and children under 5
Health problem:
Target 3.2: Reduce avoidable death in newborns and children under 5
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Leukemia
/
Lymphomas and Multiple Myeloma
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Other Malignant Neoplasms
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Neonatal Healthcare
/
Nutrition
Database:
WPRIM (Western Pacific)
Main subject:
Porifera
/
Repression, Psychology
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Retinoblastoma
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T-Lymphocytes
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Cell Line
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Apoptosis
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RNA, Untranslated
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MicroRNAs
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Cell Proliferation
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RNA, Long Noncoding
Language:
English
Journal:
The Korean Journal of Physiology and Pharmacology
Year:
2019
Document type:
Article