Niacinamide Protects Skin Cells from Oxidative Stress Induced by Particulate Matter
Biomolecules & Therapeutics
; : 562-569, 2019.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-763045
Responsible library:
WPRO
ABSTRACT
Niacinamide (NIA) is a water-soluble vitamin that is widely used in the treatment of skin diseases. Moreover, NIA displays antioxidant effects and helps repair damaged DNA. Recent studies showed that particulate matter 2.5 (PM(2.5)) induced reactive oxygen species (ROS), causing disruption of DNA, lipids, and protein, mitochondrial depolarization, and apoptosis of skin keratinocytes. Here, we investigated the protective effects of NIA on PM(2.5)-induced oxidative stress in human HaCaT keratinocytes. We found that NIA could inhibit the ROS generation induced by PM(2.5), as well block the PM(2.5)-induced oxidation of molecules, such as lipids, proteins, and DNA. Furthermore, NIA alleviated PM(2.5)-induced accumulation of cellular Ca²⁺, which caused cell membrane depolarization and apoptosis, and reduced the number of apoptotic cells. Collectively, the findings show that NIA can protect keratinocytes from PM(2.5)-induced oxidative stress and cell damage.
Full text:
Available
Health context:
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
Skin Diseases
Database:
WPRIM (Western Pacific)
Main subject:
Skin
/
Skin Diseases
/
Vitamins
/
DNA
/
Keratinocytes
/
Cell Membrane
/
Reactive Oxygen Species
/
Apoptosis
/
Niacinamide
/
Oxidative Stress
Limits:
Humans
Language:
English
Journal:
Biomolecules & Therapeutics
Year:
2019
Document type:
Article