Patterns and Biologic Features of p53 Mutation Types in Korean Breast Cancer Patients / 한국유방암학회지
Journal of Breast Cancer
; : 1-7, 2014.
Article
in En
| WPRIM
| ID: wpr-7633
Responsible library:
WPRO
ABSTRACT
PURPOSE: The p53 gene is one of the most frequently mutated genes in breast cancer. We investigated the patterns and biologic features of p53 gene mutation and evaluated their clinical significance in Korean breast cancer patients. METHODS: Patients who underwent p53 gene sequencing were included. Mutational analysis of exon 5 to exon 9 of the p53 gene was carried out using polymerase chain reaction-denaturing high performance liquid chromatography and direct sequencing. RESULTS: A total of 497 patients were eligible for the present study and p53 gene mutations were detected in 71 cases (14.3%). Mutation of p53 was significantly associated with histologic grading (p<0.001), estrogen receptor and progesterone receptor status (p<0.001), HER2 status (p<0.001), Ki-67 (p=0.028), and tumor size (p=0.004). The most frequent location of p53 mutations was exon 7 and missense mutation was the most common type of mutation. Compared with patients without mutation, there was a statistically significant difference in relapse-free survival of patients with p53 gene mutation and missense mutation (p=0.020, p=0.006, respectively). Only p53 missense mutation was an independent prognostic factor for relapse-free survival in multivariate analysis, with an adjusted hazard ratio of 2.29 (95% confidence interval, 1.08-4.89, p=0.031). CONCLUSION: Mutation of the p53 gene was associated with more aggressive clinicopathologic characteristics and p53 missense mutation was an independent negative prognostic factor in Korean breast cancer patients.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Breast
/
Breast Neoplasms
/
Receptors, Progesterone
/
Exons
/
Multivariate Analysis
/
Genes, p53
/
Chromatography, Liquid
/
Mutation, Missense
/
Estrogens
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Journal of Breast Cancer
Year:
2014
Document type:
Article