Association between Serum Selenium Level and the Presence of Diabetes Mellitus: A Meta-Analysis of Observational Studies
Diabetes & Metabolism Journal
; : 447-460, 2019.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-763665
Responsible library:
WPRO
ABSTRACT
BACKGROUND:
Epidemiological studies have suggested an association between selenium (Se) and diabetes mellitus (DM). However, different studies have reported conflicting results. Therefore, we performed a comprehensive meta-analysis to clarify the impact of Se on DM.METHODS:
We searched the PubMed database for studies on the association between Se and DM from inception to June 2018.RESULTS:
Twenty articles evaluating 47,930 participants were included in the analysis. The meta-analysis found that high levels of Se were significantly associated with the presence of DM (pooled odds ratios [ORs], 1.88; 95% confidence interval [CI], 1.44 to 2.45). However, significant heterogeneity was found (I2 =82%). Subgroup analyses were performed based on the Se measurement methods used in each study. A significant association was found between high Se levels and the presence of DM in the studies that used blood (OR, 2.17; 95% CI, 1.60 to 2.93; I2 =77%), diet (OR, 1.61; 95% CI, 1.10 to 2.36; I2 =0%), and urine (OR, 1.49; 95% CI, 1.02 to 2.17; I2 =0%) as samples to estimate Se levels, but not in studies on nails (OR, 1.24; 95% CI, 0.52 to 2.98; I2 =91%). Because of significant heterogeneity in the studies with blood, we conducted a sensitivity analysis and tested the publication bias. The results were consistent after adjustment based on the sensitivity analysis as well as the trim and fill analysis for publication bias.CONCLUSION:
This meta-analysis demonstrates that high levels of Se are associated with the presence of DM. Further prospective and randomized controlled trials are warranted to elucidate the link better.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Selenium
/
Trace Elements
/
Population Characteristics
/
Epidemiologic Studies
/
Odds Ratio
/
Prospective Studies
/
Publication Bias
/
Diabetes Mellitus
/
Diet
/
Antioxidants
Type of study:
Controlled clinical trial
/
Etiology study
/
Observational study
/
Risk factors
/
Systematic review
Aspects:
Social determinants of health
Language:
English
Journal:
Diabetes & Metabolism Journal
Year:
2019
Document type:
Article