Curcumin Elevates T(FH) Cells and Germinal Center B Cell Response for Antibody Production in Mice
Immune Network
; : e35-2019.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-764025
Responsible library:
WPRO
ABSTRACT
Curcumin is a natural product extracted from Curcuma longa. It has been reported as a potent antioxidant and anti-inflammatory compound. Previous studies have demonstrated that curcumin suppresses pro-inflammatory cytokine production via inhibition of NF-κB in macrophages. However, its role in adaptive immune cells such as T cells, in vivo, has not clearly been elucidated. Here, we examined the effects of curcumin in T follicular helper (T(FH)) cells and on Ab production during NP-ovalbumin immunization in mice. The results revealed that curcumin administered daily significantly increased CXCR5⁺B-cell lymphoma 6⁺ T(FH) cells and CD95⁺GL-7⁺ germinal center (GC) B cells in draining lymph nodes. In addition, curcumin treatment in mice induced total Ab production as well as high affinity IgG1 and IgG2b Ab production. Collectively, these results suggest that curcumin has positive regulatory roles in T(FH) cell functions and GC responses. Thus, this could be an advantageous supplement to enhance humoral immunity against infectious diseases and cancer.
Full text:
Available
Health context:
SDG3 - Health and Well-Being
Health problem:
Target 3.3: End transmission of communicable diseases
Database:
WPRIM (Western Pacific)
Main subject:
Immunoglobulin G
/
Immunoglobulins
/
B-Lymphocytes
/
T-Lymphocytes
/
Communicable Diseases
/
Immunization
/
Germinal Center
/
Curcumin
/
Curcuma
/
Immunity, Humoral
Limits:
Animals
Language:
English
Journal:
Immune Network
Year:
2019
Document type:
Article