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Postoperative Chemoradiotherapy for R1 Resected Intrahepatic Cholangiocarcinoma
Journal of Liver Cancer ; : 115-120, 2018.
Article in English | WPRIM (Western Pacific) | ID: wpr-765695
Responsible library: WPRO
ABSTRACT
BACKGROUND/

AIMS:

To investigative the potential role of postoperative chemoradiotherapy (CCRT) after R1 resection of intrahepatic cholangiocarcinoma (IHCC).

METHODS:

Between January 2000 and December 2012, medical records of 18 patients who underwent curative surgery with R1 resection for IHCC were retrospectively reviewed.

RESULTS:

Median age was 68 years and 12 patients (66.7%) were male. Median tumor size was 5.0 cm (range, 2.2–11.0) and 12 patients (66.7%) had T3 or higher disease. Lymph nodes were involved in four patients (22.2%). Vascular invasion and perineural invasion were present in 10 (55.6%) and 12 patients (66.7%), respectively. Postoperative CCRT given with 5-fluorouracil or gemcitabine were delivered to 7 patients (38.9%). Median radiation dose was 50.4 Gy (range, 45-54). Univariate analysis showed that median loco-regional recurrence-free survival (LRRFS), progression-free survival (PFS) and overall survival (OS) were prolonged for patients treated with CCRT (median LRRFS; 5.6 months vs. not reached, P < 0.001, median PFS; 5.6 vs. 8.3 months, P=0.047, median OS; 15.0 vs. 26.6 months, P=0.064).

CONCLUSIONS:

Postoperative CCRT improved the loco-regional control and PFS in IHCC patients with R1 resection. Further study is warranted to validate the role of postoperative CCRT for these patients.
Subject(s)

Full text: Available Database: WPRIM (Western Pacific) Main subject: Medical Records / Retrospective Studies / Cholangiocarcinoma / Disease-Free Survival / Chemoradiotherapy / Fluorouracil / Lymph Nodes Type of study: Observational study Limits: Humans / Male Language: English Journal: Journal of Liver Cancer Year: 2018 Document type: Article
Full text: Available Database: WPRIM (Western Pacific) Main subject: Medical Records / Retrospective Studies / Cholangiocarcinoma / Disease-Free Survival / Chemoradiotherapy / Fluorouracil / Lymph Nodes Type of study: Observational study Limits: Humans / Male Language: English Journal: Journal of Liver Cancer Year: 2018 Document type: Article
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