Association between p53 Expression and Amount of Tumor-Infiltrating Lymphocytes in Triple-Negative Breast Cancer
Journal of Pathology and Translational Medicine
; : 180-187, 2019.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-766018
Responsible library:
WPRO
ABSTRACT
BACKGROUND:
Most triple-negative breast cancers (TNBCs) have a high histologic grade, are associated with high endoplasmic stress, and possess a high frequency of TP53 mutations. TP53 missense mutations lead to the production of mutant p53 protein and usually show high levels of p53 protein expression. Tumor-infiltrating lymphocytes (TILs) accumulate as part of the anti-tumor immune response and have a strong prognostic and predictive significance in TNBC. We aimed to elucidate the association between p53 expression and the amount of TILs in TNBC.METHODS:
In 678 TNBC patients, we evaluated TIL levels and expression of endoplasmic stress molecules. Immunohistochemical examination of p53 protein expression was categorized into three groups no, low, and high expression.RESULTS:
No, low, and high p53 expression was identified in 44.1% (n = 299), 20.1% (n = 136), and 35.8% (n = 243) of patients, respectively. Patients with high p53 expression showed high histologic grade (p < .001), high TIL levels (p = .009), and high expression of endoplasmic reticulum stress-associated molecules (p-eIF2a, p = .013; XBP1, p = .007), compared to patients with low p53 expression. There was no significant difference in disease-free (p = .406) or overall survival rates (p = .444) among the three p53 expression groups.CONCLUSIONS:
High p53 expression is associated with increased expression of endoplasmic reticulum stress molecules and TIL influx.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Breast Neoplasms
/
Survival Rate
/
Lymphocytes, Tumor-Infiltrating
/
Mutation, Missense
/
Endoplasmic Reticulum
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Endoplasmic Reticulum Stress
/
Triple Negative Breast Neoplasms
Limits:
Humans
Language:
English
Journal:
Journal of Pathology and Translational Medicine
Year:
2019
Document type:
Article