Dry Eye Syndrome and Morphological Changes of Meibomian Glands in Type 2 Diabetic Patients
Journal of the Korean Ophthalmological Society
; : 1037-1042, 2019.
Article
in Korean
| WPRIM (Western Pacific)
| ID: wpr-766854
Responsible library:
WPRO
ABSTRACT
PURPOSE:
To evaluate the morphological changes of meibomian glands and dry eye syndrome in patients with type II diabetes.METHODS:
The medical records of 72 diabetic patients referred to the ophthalmology clinic for the evaluation of diabetic retinopathy, who had dry eye symptoms, were retrospectively reviewed.RESULTS:
A total of 72 patients, with an age of 56.3 ± 13.3 years, were analyzed. The group with diabetic retinopathy (52 patients) had a significantly lower tear film break-up time (p = 0.046), lower Schirmer's test value (p = 0.005), and higher percentage of upper (p = 0.036) and lower (p = 0.017) meibomian gland area losses than the group without diabetic retinopathy (20 patients). According to multilinear regression analyses considering sex, age, and diabetes-related characteristics, the Schirmer's test value was significantly lower with increasing stage of diabetic retinopathy (β = −1.180, p = 0.016). The percentage of upper meibomian gland area loss was significantly increased with increasing age (β = 0.605, p < 0.001), glycosylated hemoglobin (β = 1.881, p = 0.011), and stage of diabetic retinopathy (β = 4.458, p = 0.001). The percentage of lower meibomian gland loss area was significantly increased with increasing age (β = 0.443, p = 0.001) and stage of diabetic retinopathy (β = 4.879, p = 0.001).CONCLUSIONS:
In patients with type 2 diabetes, the more severe the diabetic retinopathy, the more likely the meibomian gland loss will occur, so careful and appropriate treatment should be conducted.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Ophthalmology
/
Tears
/
Glycated Hemoglobin
/
Dry Eye Syndromes
/
Medical Records
/
Retrospective Studies
/
Diabetic Retinopathy
/
Meibomian Glands
Type of study:
Observational study
Limits:
Humans
Language:
Korean
Journal:
Journal of the Korean Ophthalmological Society
Year:
2019
Document type:
Article