Advance in research on recycling antibody / 生物工程学报
Chinese Journal of Biotechnology
; (12): 183-194, 2019.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-771388
Responsible library:
WPRO
ABSTRACT
Monoclonal antibodies have become the main type of antibody drug because of their high specificity and strong affinity to antigen. However, with the intensive study of the natural monoclonal antibody, many defects have faced, such as the limit times of binding to antigen, the unanticipated antibody clearance and antigen accumulation. Therefore, studies are no longer limited to the natural antibody screening, but rather to improve the efficiency of antibody drugs by engineering. In recent years, the bottlenecks in the development of conventional antibody have been solved effectively since the discovery of a novel recycling antibody. Recycling antibody binds to an antigen in plasma and dissociates from the antigen in endosome, thus maximizing the use of antibody and reducing antigen-mediated antibody clearance and antibody-mediated antigen accumulation. In addition, recycling antibodies can enhance the affinity with Fc receptors through further Fc modification. This paper reviews the research progress of circulating antibodies, including its characteristics, transformation methods and prospects.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Protein Binding
/
Endosomes
/
Receptors, Fc
/
Allergy and Immunology
/
Antibodies, Monoclonal
/
Antigens
Language:
Chinese
Journal:
Chinese Journal of Biotechnology
Year:
2019
Document type:
Article