Limonoids from seeds of Azadirachta indica and their cytotoxic activity / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 537-543, 2018.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-771704
Responsible library:
WPRO
ABSTRACT
Eight limonoids were isolated from 95% ethanol extracts of neem(Azadirachta indica) seeds by various chromatographic methods. By comparison of their spectroscopic data with those reported in the literatures, these limonoids were determined as salannin(1), 1-detigloyl-1-isobutylsalannin(2), salannol-3-acetate(3), salannol(4), spirosendan(5), 1-detigloyloxy-3-deacetylsalannin-1-en-3-one(6), nimbin(7) and 6-deacetylnimbin(8). Compounds 2 and 5 were firstly isolated from this genus and 5 represented the only example of its type. And 6 is a new natural product. 6 showed inhibitory activity against HeLa and HL-60 cells, with IC₅₀ of(21.61±4.37) and(27.33±5.74) μmol·L⁻¹, respectively. Both 7 and 8 mildly inhibited the growth of HeLa cells, with IC₅₀ of (33.15±5.24) and (38.56±6.41) μmol·L⁻¹, respectively.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pharmacology
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Seeds
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Plant Extracts
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HeLa Cells
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Chemistry
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HL-60 Cells
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Azadirachta
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Limonins
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Phytochemicals
Limits:
Humans
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2018
Document type:
Article