Incompatible mechanism of compatibility of Chinese medicines based on Qianjinzi and Gancao effect on intestinal flora/barrier system / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 369-371, 2018.
Article
in Zh
| WPRIM
| ID: wpr-771728
Responsible library:
WPRO
ABSTRACT
The study was based on the toxic characteristics of the compatibility between "Zaojisuiyuan" and Gancao, with intestinal tract and intestinal bacteria as subject. From the angle of intestinal barrier function, motor function, steady state of intestinal flora and metabolism genes, the toxic and side effects of the compatibility between Qianjinzi and Gancao with similar properties, bases and chemical composition and types were further explored. The results showed that the combined application of Qianjinzi and Gancao enhanced intestinal mucosa damage, and led to abnormal changes in intestinal bacteria structure and metabolic function. It improved the degradation functions of mucus and aromatic amino acids on intestinal bacteria, which may increase the risk of disease and derived from intestinal urotoxin and other toxic substances. This study considered intestinal bacteria as an important target to study the interactions of traditional Chinese medicine. The "drug-intestinal bacteria-metabolism-toxicity" was applied in the experiment. Meanwhile, it provides ideas for exploring incompatible mechanism of traditional Chinese medicines.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Pathology
/
Pharmacology
/
Drugs, Chinese Herbal
/
Chemistry
/
Glycyrrhiza uralensis
/
Gastrointestinal Microbiome
/
Intestinal Mucosa
/
Medicine, Chinese Traditional
Type of study:
Diagnostic_studies
Limits:
Animals
Language:
Zh
Journal:
China Journal of Chinese Materia Medica
Year:
2018
Document type:
Article