Recent transmission of Mycobacterium tuberculosis in China: the implication of molecular epidemiology for tuberculosis control / 医学前沿
Frontiers of Medicine
; (4): 76-83, 2018.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-772729
Responsible library:
WPRO
ABSTRACT
Tuberculosis (TB) has remained an ongoing concern in China. The national scale-up of the Directly Observed Treatment, Short Course (DOTS) program has accelerated the fight against TB in China. Nevertheless, many challenges still remain, including the spread of drug-resistant strains, high disease burden in rural areas, and enormous rural-to-urban migrations. Whether incident active TB represents recent transmission or endogenous reactivation has helped to prioritize the strategies for TB control. Evidence from molecular epidemiology studies has delineated the recent transmission of Mycobacterium tuberculosis (M. tuberculosis) strains in many settings. However, the transmission patterns of TB in most areas of China are still not clear. Studies carried out to date could not capture the real burden of recent transmission of the disease in China because of the retrospective study design, incomplete sampling, and use of low-resolution genotyping methods. We reviewed the implementations of molecular epidemiology of TB in China, the estimated disease burden due to recent transmission of M. tuberculosis strains, the primary transmission of drug-resistant TB, and the evaluation of a feasible genotyping method of M. tuberculosis strains in circulation.
Full text:
Available
Health context:
Sustainable Health Agenda for the Americas
/
SDG3 - Health and Well-Being
/
Neglected Diseases
Health problem:
Goal 10: Communicable diseases
/
Target 3.3: End transmission of communicable diseases
/
Neglected Diseases
/
Tuberculosis
Database:
WPRIM (Western Pacific)
Main subject:
China
/
Epidemiology
/
Tuberculosis, Multidrug-Resistant
/
Molecular Epidemiology
/
Genotyping Techniques
/
Whole Genome Sequencing
/
Genetics
/
Mycobacterium tuberculosis
Type of study:
Observational study
/
Screening study
Limits:
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Frontiers of Medicine
Year:
2018
Document type:
Article