Low-dose CT for lung cancer screening: opportunities and challenges / 医学前沿
Frontiers of Medicine
; (4): 116-121, 2018.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-772738
Responsible library:
WPRO
ABSTRACT
Lung cancer is among the most frequently diagnosed cancers worldwide and the leading cause of cancer death in both males and females. Screening for lung cancer coupled with earlier intervention has long been studied as an approach to mortality reduction. However, minimal progress was achieved until recently, when lowdose spiral computed tomography (LDCT) screening demonstrated a 20% reduction in mortality from lung cancer in a randomized controlled trial (RCT), the National Lung Screening Trial, from the United States. On the basis of this finding, LDCT has been recommended for lung cancer screening in high-risk populations by several clinical guidelines. However, results from the following independent RCTs in Europe failed to show consistent conclusions. In addition, intractable problems gradually emerged with the progress of LDCTscreening. This paper summarizes and discusses the main observations and challenges of LDCT screening for lung cancer. Before spreading implementation of LDCTscreening, challenges, including high false-positive rates, overdiagnosis, enormous costs, and radiation risk, must be addressed. Complementary biomarkers and technical improvement are expected in the field of lung cancer screening in the near future.
Full text:
Available
Health context:
SDG3 - Health and Well-Being
/
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
Target 3.4: Reduce premature mortality due to noncommunicable diseases
/
Other Respiratory Diseases
/
Trachea, Bronchus, Lung Cancers
Database:
WPRIM (Western Pacific)
Main subject:
Radiation Dosage
/
Diagnostic Imaging
/
Tomography, X-Ray Computed
/
Randomized Controlled Trials as Topic
/
Mass Screening
/
Risk Factors
/
Mortality
/
Early Detection of Cancer
/
Lung Neoplasms
/
Methods
Type of study:
Controlled clinical trial
/
Diagnostic study
/
Etiology study
/
Practice guideline
/
Prognostic study
/
Risk factors
/
Screening study
Limits:
Humans
Language:
English
Journal:
Frontiers of Medicine
Year:
2018
Document type:
Article