Carbazole alkaloids isolated from the branch and leaf extracts of Clausena lansium / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 509-512, 2018.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-773589
Responsible library:
WPRO
ABSTRACT
The present study carried out a phytochemical investigation of the methanol extract of the branches and leaves of Clausena lansium and afforded nine carbazole alkaloids (compounds 1-9) including two new carbazole alkaloids, claulansiums A and B (compounds 1 and 2). The new compounds were elucidated on the basis of extensive spectroscopic data (MS, NMR, IR, and UV) and the known compounds were identified by comparing spectroscopic data with those reported in literature. All the isolated compounds were tested for their cytotoxic activity against A549 and Hela cancer cell lines. Our results showed that compounds 2-6 exhibited varying degrees of cytotoxicity to cancer cells, with IC values ranging from 8.67 to 98.89 μmol·L.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Plants, Medicinal
/
Carbazoles
/
Plant Extracts
/
HeLa Cells
/
Molecular Structure
/
Cell Survival
/
Chemistry
/
Plant Stems
/
Plant Leaves
/
Cell Line, Tumor
Limits:
Humans
Language:
English
Journal:
Chinese Journal of Natural Medicines (English Ed.)
Year:
2018
Document type:
Article