Enhancement of gut permeation of amoxicillin with Nigella sativa seed extract and its phytochemical screening / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 125-130, 2018.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-773634
Responsible library:
WPRO
ABSTRACT
The seeds of Nigella sativa Linn. (Ranunculaceae), commonly known as Black cumin, are predominantly used as carminative, antispasmodic, and stimulant. The main objective of the present study was to evaluate the effect of N. sativa seed extract on the permeation of co-infused amoxicillin across the gut wall. The methanolic extract of N. sativa improved intestinal permeability of amoxicillin in in-vitro experiments in a dose-dependent manner. Two new glycosides, decanyl nigelloic acid diglucoside [n-decanyl-3-aldehydic-4-methoxy-5-hydroxy benzoate-5-β-D-glucofuranosyl (2→1)-β-D-glucopyranosyl-(2→1)-β-D-glucopyranoside]] and nigelabdienoyl triglucoside [homo-labd-5, 9(11)-dien-16-onyl-β-D-glucopyranosyl (2→1)-β-D-glucopyranosyl (2→1)-β-D-glucopyranoside], along with seven known fatty acid glycerides/esters, were isolated from the gut permeation enhancing extract. The structures of these new glycosides were elucidated by detailed spectroscopic analyses.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Seeds
/
Pharmacokinetics
/
Plant Extracts
/
Molecular Structure
/
Chemistry
/
Nigella sativa
/
Rats, Wistar
/
Phytochemicals
/
Amoxicillin
/
Intestine, Small
Type of study:
Diagnostic study
/
Screening study
Limits:
Animals
Language:
English
Journal:
Chinese Journal of Natural Medicines (English Ed.)
Year:
2018
Document type:
Article