Transanal endoscopic microsurgery for local excision of rectal gastrointestinal stromal tumors / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery
; (12): 1296-1300, 2018.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-774455
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To investigate the efficacy of transanal endoscopic microsurgery (TEM) combined with imatinib for rectal gastrointestinal stromal tumors(GIST).@*METHODS@#Clinical data of 35 patients with rectal GIST undergoing TEM at Peking Union Medical College Hospital from February 2008 to May 2017 were analyzed retrospectively. Operation details, postoperative recovery condition, and follow-up information were reviewed. The differences in clinicopathological features and perioperative parameters were compared between patients who received neoadjuvant therapy (12 patients, imatinib mesylate, oral, 400 mg daily for 6 months before surgery) and those without neoadjuvant therapy (23 patients).@*RESULTS@#Of 35 patients, 18 were males and 17 were females with the mean age of (49.3±13.3) years. Mean tumor diameter was (1.8±1.1) cm and mean distance from lower tumor margin to anal verge was (4.0±1.8) cm. Mean operative time was (82.4±21.1) minutes and mean blood loss was (11.7±7.5) ml. No conversion to laparotomy occurred. Complete resection with negative margins was achieved in all cases. Complications were classified according to Clavien-Dindo system 4 cases of grade I, 3 of grade II and 1 of grade IIIb. The tumor size in patients who received neoadjuvant therapy reduced from (3.1±1.2) cm to (2.6±1.2) cm, though it was still larger than the tumor size in patients without neoadjuvant therapy[(1.5±0.8) cm, P0.05]. Thirty patients (85.7%) were followed up for (50.3±36.6) months, and no local recurrence or metastasis was observed.@*CONCLUSIONS@#TEM is safe and effective in the treatment of rectal GIST. Preoperative neoadjuvant therapy is beneficial to TEM in treating larger tumors without increasing operating time. Satisfactory follow-up result is observed.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Rectal Neoplasms
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Reference Standards
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General Surgery
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Retrospective Studies
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Treatment Outcome
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Therapeutic Uses
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Gastrointestinal Stromal Tumors
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Drug Therapy
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Imatinib Mesylate
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Transanal Endoscopic Microsurgery
Type of study:
Observational study
Limits:
Adult
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Female
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Humans
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Male
Language:
Chinese
Journal:
Chinese Journal of Gastrointestinal Surgery
Year:
2018
Document type:
Article