Spinal Cord Stimulation for Pain Treatment After Spinal Cord Injury / 神经科学通报·英文版
Neuroscience Bulletin
; (6): 527-539, 2019.
Article
in En
| WPRIM
| ID: wpr-775442
Responsible library:
WPRO
ABSTRACT
In addition to restoration of bladder, bowel, and motor functions, alleviating the accompanying debilitating pain is equally important for improving the quality of life of patients with spinal cord injury (SCI). Currently, however, the treatment of chronic pain after SCI remains a largely unmet need. Electrical spinal cord stimulation (SCS) has been used to manage a variety of chronic pain conditions that are refractory to pharmacotherapy. Yet, its efficacy, benefit profiles, and mechanisms of action in SCI pain remain elusive, due to limited research, methodological weaknesses in previous clinical studies, and a lack of mechanistic exploration of SCS for SCI pain control. We aim to review recent studies and outline the therapeutic potential of different SCS paradigms for traumatic SCI pain. We begin with an overview of its manifestations, classification, potential underlying etiology, and current challenges for its treatment. The clinical evidence for using SCS in SCI pain is then reviewed. Finally, future perspectives of pre-clinical research and clinical study of SCS for SCI pain treatment are discussed.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Pain
/
Quality of Life
/
Spinal Cord Injuries
/
Treatment Outcome
/
Chronic Pain
/
Pain Management
/
Spinal Cord Stimulation
/
Methods
Aspects:
Patient_preference
Limits:
Animals
/
Humans
Language:
En
Journal:
Neuroscience Bulletin
Year:
2019
Document type:
Article