Curative Effect of Simply Hormone and Combined Gamma Globulin and Thrombopoietin on Primary Immune Thrombocytopenia / 中国实验血液学杂志

ABSTRACT

OBJECTIVE@#To investigate the curative effect of simply hormone and combined gamma globulin and thrombopoietin(TPO) on primary immune thrombocytopenia(PITP).@*METHODS@#100 patients with PITP were divided into simply drug groups, and combined drug group each for 50 cases. The patients in single drug group were given simply hormone therapy, the patients in combined drug group were given gamma globulin and thrombopoietin. The levels of TPO, platelet activating factor (PAF) were detected by DAS-ELISA. The differences of clinical curative effect, clinical indicators, biochemical indexes and adverse reactions between the two groups were compared.@*RESULTS@#The total effective rate of combined drug group (90.00%) was obviously higher than that in single drug group (66.00%)(P0.05), however, the above-mentioned indexes of two groups after treatment were lower than those before treatment (P0.05), the recurrence rate in combined drug group(2%) was obviously lower than that in single group(14.00%) (P<0.05).@*CONCLUSION@#The curative effect of hormone, as well as gamma globulin combined with TPO to treat PITP are satisfying, can obviously improve the levels of TPO, PAF, and the drug safety is higher. but the efficacy of combined drug is surperior to single drug.