Exploration of Postoperative Follow-up Strategies for Early Staged NSCLC Patients on the Basis of Follow-up Result of 416 Stage I NSCLC Patients after Lobectomy / 中国肺癌杂志
Chinese Journal of Lung Cancer
; (12): 199-203, 2018.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-776324
Responsible library:
WPRO
ABSTRACT
BACKGROUND@#Currently, there is no consensus on the follow-up strategy (follow-up time interval and content) of non-small cell lung cancer (NSCLC) in the world, and the relevant clinical evidence is also very limited. In this study, we aimed to summarize the recurrence/metastasis sites and timings of stage I NSCLC patients based on their follow-up data, aiming to provide a basis of follow-up time interval and content for this group of patients.@*METHODS@#We retrospectively analyzed the 416 stage I NSCLC patients that underwent continuous anatomic lobectomy between Jan. 2000 to Oct. 2013 in our prospective lung cancer database. According to the recurrence/metastasis sites and timings, the long term follow-up time interval and content were explored.@*RESULTS@#The 5-yr disease free survival (DFS) and overall survival (OS) in the whole group were 82.4% and 85.4%, respectively. There were 76 cases (18.3%) had recurrence/metastasis during follow-up, among which the most frequent site was pulmonary metastasis (21 cases, 5.0%), followed by brain metastasis (20 cases, 4.8%), bone metastasis (12 cases, 2.9%), and mediastinal lymph node metastasis (12 cases, 2.9%). Among the factors that could influence recurrence/metastasis, patients with pT2a suffered from a higher recurrence/metastasis rate compared to patients with pT1 (P=0.006), with 5-yr DFS being 73.8% and 87.3%, respectively (P=0.002), and the 5-yr OS being 77.7% and 90.3%, respectively (P=0.011).@*CONCLUSIONS@#The commonest recurrence/metastasis sites of stage I NSCLC after anatomic lobectomy are lung, brain and mediastinal lymph nodes, the risk of recurrence/metastasis within 2 years were equal to that between 3 years and 5 years. The follow-up frequencies and content within 2 years could be adjusted according to T stages.
Full text:
Available
Health context:
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
Other Malignant Neoplasms
/
Other Respiratory Diseases
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Trachea, Bronchus, Lung Cancers
Database:
WPRIM (Western Pacific)
Main subject:
Pathology
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Pneumonectomy
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General Surgery
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Prospective Studies
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Retrospective Studies
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Follow-Up Studies
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Mortality
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Carcinoma, Non-Small-Cell Lung
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Lung Neoplasms
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Lymph Nodes
Type of study:
Observational study
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Prognostic study
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Risk factors
Limits:
Adolescent
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Adult
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Aged
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Aged, 80 and over
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Female
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Humans
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Male
Language:
Chinese
Journal:
Chinese Journal of Lung Cancer
Year:
2018
Document type:
Article