Effects of Mitochondrial Dysfunction via AMPK/PGC-1 α Signal Pathway on Pathogenic Mechanism of Diabetic Peripheral Neuropathy and the Protective Effects of Chinese Medicine / 中国结合医学杂志
Chinese journal of integrative medicine
; (12): 386-394, 2019.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-776594
Responsible library:
WPRO
ABSTRACT
Diabetic peripheral neuropathy (DPN) is a progressive neurodegenerative disease of peripheral nervous system with high energy requirement. The adenosine monophosphate-activated protein kinase (AMPK)/peroxisome proliferator-activated receptor- γ coactivator 1 α (PGC-1 α) axis plays a key role in regulating mitochondrial energy metabolism. Increasing preclinical evidences have shown that inhibition of AMPK/PGC-1 α pathway leading to mitochondrial dysfunction in neurons or Schwann cells contributes to neuron apoptosis, distal axonopathy and nerve demyelination in DPN. Some Chinese medicine formulae or extracts from herbs may have potential neuroprotective effects on DPN via activating AMPK/PGC-1 α pathway and improving mitochondrial function.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Signal Transduction
/
Neuroprotective Agents
/
Therapeutic Uses
/
Diabetic Neuropathies
/
Drug Therapy
/
AMP-Activated Protein Kinases
/
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
/
Medicine, Chinese Traditional
/
Metabolism
Type of study:
Diagnostic study
Limits:
Humans
Language:
English
Journal:
Chinese journal of integrative medicine
Year:
2019
Document type:
Article