Research advance in circular RNAs / 生理学报
Acta Physiologica Sinica
; (6): 613-624, 2019.
Article
in Zh
| WPRIM
| ID: wpr-777149
Responsible library:
WPRO
ABSTRACT
Circular RNAs (circRNAs) are a class of endogenous, covalently closed, single-stranded RNA without 3'-poly(A) and 5'-cap structures. CircRNAs are characterized by universality, diversity, stability and conservation, and have been found to regulate mammalian transcription and be translated into proteins. In this review, we summarized the biogenesis, classification, expression, distribution, biological functions and regulation of circRNAs. In addition, we discussed the association of circRNAs with diseases and the methods for identification and characterization of circRNAs. Finally, we speculated the application prospect and research direction of circRNAs.
Full text:
1
Database:
WPRIM
Main subject:
Research
/
RNA
/
Genetics
Limits:
Animals
Language:
Zh
Journal:
Acta Physiologica Sinica
Year:
2019
Document type:
Article