Modulation of drug-metabolizing enzymes and transporters under hypoxia environment / 生理学报
Acta Physiologica Sinica
; (6): 336-342, 2019.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-777181
Responsible library:
WPRO
ABSTRACT
Drug metabolism is significantly affected under hypoxia environment with changes of pharmacokinetics, expression and function of drug-metabolizing enzymes and transporters. Studies have shown that hypoxia increases the release of a series of inflammatory cytokines which can modulate drug metabolism. Besides, both hypoxia inducible factor 1α (HIF-1α) and microRNA-mediated pathways play a role in regulating drug metabolism. This article reviewed the impact and single-factor modulating mechanisms of drug metabolism under hypoxia, and put forward the speculation and prospects of multi-factor modulating mechanisms.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Membrane Transport Proteins
/
Physiology
/
Pharmaceutical Preparations
/
Cell Hypoxia
/
MicroRNAs
/
Hypoxia-Inducible Factor 1, alpha Subunit
/
Hypoxia
/
Metabolism
Limits:
Humans
Language:
Chinese
Journal:
Acta Physiologica Sinica
Year:
2019
Document type:
Article