Prevalence of hepatitis C virus infection and the IL28B genotype polymorphism among blood donors and high-risk populations
Singapore medical journal
; : 34-39, 2019.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-777551
Responsible library:
WPRO
ABSTRACT
INTRODUCTION@#To study the prevalence of hepatitis C virus (HCV) infection in blood donor (BD), haemodialysis (HD) and intravenous drug user (IVDU) populations in Singapore and assess the IL28B polymorphism if HCV positive.@*METHODS@#The BD population were healthy volunteers, the HD population were patients who were on haemodialysis for at least six months of follow-up between January 2009 and December 2014. IVDU population was from inmates at halfway houses who consented.@*RESULTS@#Between 2011 and 2014, of 161,658 individuals who underwent screening prior to blood donation, 95 (0.059%) were positive for HCV. Of the 42 sera available, common genotypes (GTs) were GT-3 (47.6%) and GT-1 (31.0%). Of 1,575 HD patients, 2.2% were anti-HCV positive. The HCV GT distribution was HCV GT-1 (32.4%), HCV GT-3 (20.5%) and GT-6 (8.8%). 83 halfway house inmates were screened. Of the 47 IVDUs, 36.2% were anti-HCV positive with predominant GT-3 (%). IL28B polymorphism was noted to be CC predominantly 85.3%.@*CONCLUSION@#Prevalence of HCV infection has decreased in both the BD and HD populations. However, it remains high in the IVDU population. GT-1 remains the most common in the HD population; however, GT-3 infection is now more common among the BD population in Singapore. IL28B - CC is the predominant variant among the HCV-infected individuals in Singapore.
Full text:
Available
Health context:
SDG3 - Health and Well-Being
Health problem:
Target 3.5: Prevention and treatment of consumption of psychoactive substances
Database:
WPRIM (Western Pacific)
Main subject:
Singapore
/
Blood
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Blood Donors
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Substance Abuse, Intravenous
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Epidemiology
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Prevalence
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Renal Dialysis
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Interleukins
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Hepatitis C
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Polymorphism, Single Nucleotide
Type of study:
Etiology study
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Prevalence study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
Singapore medical journal
Year:
2019
Document type:
Article