Metastasis-Free Interval Is Closely Related to Tumor Characteristics and Has Prognostic Value in Breast Cancer Patients with Distant Relapse / 한국유방암학회지
Journal of Breast Cancer
; : 371-377, 2015.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-77779
Responsible library:
WPRO
ABSTRACT
PURPOSE:
We investigated the relationships between metastasis-free interval (MFI) and tumor characteristics, and assessed the prognostic value of MFI for survival after metastasis in patients with metastatic breast cancer. Furthermore, we compared MFI among the subtypes.METHODS:
We identified 335 patients with postoperative tumor recurrence at distant site(s). All patients underwent curative resection and had a MFI of at least 6 months. MFI was categorized as short ( or =2 years and or =5 years). Overall survival after metastasis (OSM) was estimated.RESULTS:
Patients with a shorter MFI were younger, more likely to have initial metastasis to visceral organs, and had a larger tumor with a higher stage and grade as well as a higher rate of nodal involvement at initial diagnosis. Among 136 patients with known disease subtypes, shorter MFI was associated with the triple-negative subtype while longer MFI was associated with the hormone receptor-positive/human epidermal growth factor receptor 2 negative subtype. Mortality after metastasis declined sharply with increasing MFI up to approximately 2 years, and continued gradually declining between 2 and 5 years. An MFI longer than 5 years did not add any survival benefit. MFI was a significant prognostic factor for OSM independent of nodal status, stage, metastatic site, and hormone receptor status of the metastasized cancer.CONCLUSION:
MFI is closely related to biological characteristics of both primary tumors and their metastases, and has a prognostic value for survival after metastasis. We therefore suggest investigation into treatments targeting improvement of MFI as a potential novel strategy.
Full text:
Available
Health context:
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
Breast Cancer
Database:
WPRIM (Western Pacific)
Main subject:
Recurrence
/
Population Characteristics
/
Breast
/
Breast Neoplasms
/
Mortality
/
Diagnosis
/
ErbB Receptors
/
Neoplasm Metastasis
Type of study:
Diagnostic study
/
Prognostic study
Aspects:
Social determinants of health
Limits:
Humans
Language:
English
Journal:
Journal of Breast Cancer
Year:
2015
Document type:
Article