High MicroRNA-370 Expression Correlates with Tumor Progression and Poor Prognosis in Breast Cancer / 한국유방암학회지
Journal of Breast Cancer
; : 323-328, 2015.
Article
in En
| WPRIM
| ID: wpr-77785
Responsible library:
WPRO
ABSTRACT
PURPOSE: Deregulation of microRNA-370 (miR-370) has been reported in various cancers, in which it can act as either an oncogene or a tumor suppressor gene. However, the clinicopathologic significance of miR-370 expression in breast cancer has not been studied. METHODS: The expression of miR-370 was determined with quantitative real-time polymerase chain reaction in 60 formalin-fixed, paraffin-embedded primary breast cancer tissues. Additionally, the protein expression levels of previously known targets of miR-370, such as FOXM1, FOXO1, and FOXO3a, were detected using immunohistochemistry. Finally, we analyzed its correlation with target protein expression, clinicopathologic features, and clinical outcome. RESULTS: High levels of miR-370 expression correlated with lymph node metastasis (p=0.009), advanced stage (p=0.002), and frequent perineural invasion (p=0.042). Moreover, patients with high miR-370 expression had poor disease-free survival compared with the low-expression group. However, no correlation was observed between miR-370 and its target protein expression. CONCLUSION: Our results indicate that upregulation of miR-370 in breast cancer is correlated with breast cancer progression and that it might be a potential biomarker for predicting clinical outcomes.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Oncogenes
/
Prognosis
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Breast
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Breast Neoplasms
/
Immunohistochemistry
/
Up-Regulation
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Genes, Tumor Suppressor
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Disease-Free Survival
/
Real-Time Polymerase Chain Reaction
/
Lymph Nodes
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Journal of Breast Cancer
Year:
2015
Document type:
Article