Analysis of the indicators of frequent exacerbation of chronic obstructive pulmonary disease / 中华疾病控制杂志

ABSTRACT

@# Objective To investigate the relationship between multiple blood indexes and frequent exacerbation of chronic obstructive pulmonary disease (COPD). Methods 102 patients with COPD were selected and divided into frequent exacerbation group (≥ 2 times/year, 55 patients) and infrequent exacerbation group (< 2 times/year, 47patients), according to the frequency of acute exacerbation in one year. The relationship between multiple indicators in blood routine and blood gas analysis and frequent exacerbation of COPD was explored by independent sample t test, 2 test, and multiple Logistic regression analysis. A retrospective study was conducted. Results Neutrophils count (NEU), neutrophils ratio (Neut%), and neutrophil-to-lymphocyte ratio (NLR) of frequent exacerbation group were significantly higher than those of infrequent exacerbation group, while lymphocytes (LY), lymphocytes ratio (LY%) were lower (All P<0.05). OR(95% CI) of NLR was 3.483(1.170-10.373)，and OR(95% CI) of partial pressure of carbon dioxide in artery (PaCO2) was 1.124(1.053-1.201).NLR and PaCO2 were risk factors for frequent exacerbation of COPD. Increase of NLR and PaCO2 led to an increasing risk of frequent exacerbation of COPD ( All P<0.05). Conclusions The levels of NLR and PaCO2 in COPD patients with frequent exacerbation are higher than those in patients with infrequent exacerbation. As a consequent, NLR and PaCO2 could be considered risk factors for frequent exacerbation of COPD.