Disruption of iron homeostasis and relevant pharmacotherapies in Alzheimer's disease / 药学学报
Acta Pharmaceutica Sinica
; (12): 866-2016.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-779249
Responsible library:
WPRO
ABSTRACT
Iron is the most abundant metal element to support the body's physiological activities and play crucial roles in the central nervous system. Iron homeostasis is under strict control in normal circumstances, and some diseases will occur once the homeostasis was disrupted. Numerous researches suggest that iron homeostasis disruptes in Alzheimer's disease (AD) and the homeostasis disruption interacts with AD's hallmarks. Dispute still exists on how iron plays a role in AD despite of the great number of researches. This article will focus on iron metabolism, normal function in the brain and recent therapies of AD based on iron chelation.
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2016
Document type:
Article