The application of poly (2-ethyl-2-oxazoline) in drug delivery system / 药学学报
Acta Pharmaceutica Sinica
; (12): 1235-1240, 2017.
Article
in Zh
| WPRIM
| ID: wpr-779717
Responsible library:
WPRO
ABSTRACT
Poly(2-ethyl-2-oxazoline) (PEOz), a hydrophilic long-chain polymer synthesized by living cationic ring-opening isomerization polymerization of 2-ethyl-2-oxazoline, has the characteristics of low toxicity, biocompatibility, flexible chain, and modified expediently. PEOz is a potential substitute of polyethylene glycol (PEG) to render the ability of long-circulation, enhance cellular uptake and endosomal escape behaviors to PEOz modified drug delivery system. In this review, we summarized recent literature for the research progress of physicochemical properties, synthetic methods and the application of PEOz in drug delivery system.
Full text:
1
Database:
WPRIM
Language:
Zh
Journal:
Acta Pharmaceutica Sinica
Year:
2017
Document type:
Article