Lead compound optimization strategy (6)-improving the plasma stability / 药学学报
Acta Pharmaceutica Sinica
; (12): 192-201, 2018.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-779863
Responsible library:
WPRO
ABSTRACT
Plasma stability plays an important role in the druggability of lead compound. Improving the plasma stability of compounds by structural modification can lead to good pharmacokinetic and pharmacodynamics properties. This review provides a summary of varieties of structure modification strategies for improving plasma stability including bioisosterism, increasing steric hindrance, ring closure, scaffold hopping and etc.
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2018
Document type:
Article