Multivariate statistical analysis for metabolomic data: the key points in principal component analysis / 药学学报
Acta Pharmaceutica Sinica
; (12): 929-937, 2018.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-779953
Responsible library:
WPRO
ABSTRACT
Metabolomics data contains multiple variables usually processed and evaluated by means of principal components analysis. The statistical analysis of the multivariate data is involved in abstract, elusory fitting for the model of hyperspace, complicated theoretical arithmetic and sophisticated transformation of the data matrix. It is crucially important to understand the arithmetic mechanism and the properties of the models fully. In this article, we reviewed the key and puzzling issues in principal components analysis of the metabolomics data, including the principal components, the scores and loadings of a principal components, scaling and weighting, partial least square projection to latent structures, partial least squares discriminant analysis, orthogonal projection to latent structure, orthogonal bidirectional projections to latent structures, S-plot, shared and unique structure plot, and the validation of the model. Hopefully, this article provides a better understanding of data processing mode, model selection, procedure standardization, and data interpretation for a reliable conclusion.
Full text:
Available
Database:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2018
Document type:
Article