Recent advances in study of drugs against Gram-negative pathogens / 药学学报
Acta Pharmaceutica Sinica
; (12): 1554-1563, 2019.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-780266
Responsible library:
WPRO
ABSTRACT
The long-term use of antibiotics in clinical practice leads to bacterial variation and resistance. In addition, the excessive or improper use of antibiotics in medical and agricultural fields increases the occurrence of bacterial resistance. In 2017, the World Health Organization has for the first time released a list of 12 bacteria or bacterial families that pose the greatest threat to human health and for which new antibiotics are desperately needed, and three quarters of them are Gram-negative bacteria. Gram-negative bacteria has multi-layered cell wall that prevents many antibiotics from accessing their targets. Therefore, it is very difficult to develop drugs against Gram-negative bacteria, no new class of antibiotic has been approved for Gram-negative pathogens in over fifty years. Here, we summarized recent advances in the study of new antibacterial agents with different mechanisms of action against Gram-negative pathogens.
Full text:
Available
Health context:
SDG3 - Health and Well-Being
Health problem:
Target 3.8 Achieve universal access to health
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2019
Document type:
Article