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Research Advance on Classic Wnt Pathway in Chronic Myelogenous Leukemia--Review / 中国实验血液学杂志
Article in Chinese | WPRIM (Western Pacific) | ID: wpr-781439
Responsible library: WPRO
ABSTRACT
Abstract  Chronic myelogenous leukemia (CML) is a hematological malignancy that seriously threatens the lives of patients. It was found that there are abnormal classic Wnt pathway, that is, Wnt/β-catenin signaling pathways in CML cells, moreover, Wnt/β-catenin signaling pathway is involved in the growth and proliferation of CML cells, and closely relates with the self-renewal ability of CML leukemic stem cells. This review summarizes the recent studies on the relationship between Wnt/β-catenin signaling pathway and CML, and the researches on the targeting inhibition of Wnt/β-catenin signaling pathway in CML treatment, thus to provide new ideas for the treatment of CML.
Full text: Available Database: WPRIM (Western Pacific) Language: Chinese Journal: Journal of Experimental Hematology Year: 2020 Document type: Article
Full text: Available Database: WPRIM (Western Pacific) Language: Chinese Journal: Journal of Experimental Hematology Year: 2020 Document type: Article
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