Non-coplanar whole brain radiotherapy is an effective modality for parotid sparing / 영남의대학술지
Yeungnam University Journal of Medicine
; : 36-42, 2019.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-785298
Responsible library:
WPRO
ABSTRACT
BACKGROUND:
The purpose of this study was to evaluate the efficacy and feasibility of non-coplanar whole brain radiotherapy (NC-WBRT) for parotid sparing.METHODS:
Fifteen cases, previously treated with WBRT were selected. NC-WBRT plans were generated. The beam arrangement for the non-coplanar plans consisted of superior anterior, right, and left beams. After generation of the non-coplanar plans a field-in-field technique was applied to the bilateral parallel opposed beams in order to reduce maximum dose and increase dose homogeneity. The NC-WBRT plans were subsequently compared with the previously generated bilateral WBRT (B-WBRT) plans. A field-in-field technique was also used with the B-WBRT plans according to our departmental protocol. As per our institutional practice a total dose of 30 Gy in 10 fractions of WBRT was administered 5 days a week.RESULTS:
The mean dose to the parotid gland for the two different plans were 16.2 Gy with B-WBRT and 13.7 Gy with NC-WBRT (p < 0.05). In the NC-WBRT plan, the V5Gy, V10Gy, V15Gy, V20Gy, and V25Gy of the parotid were significantly lower (p < 0.05) than those of the B-WBRT plan. The Dmax of the lens was also lower by 10% with NC-WBRT.CONCLUSION:
The use of NC-WBRT plans could be a simple and effective method to reduce irradiated volumes and improve the dose-volume parameters of the parotid gland.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Parotid Gland
/
Radiotherapy
/
Xerostomia
/
Brain
/
Institutional Practice
/
Methods
Type of study:
Practice guideline
Language:
English
Journal:
Yeungnam University Journal of Medicine
Year:
2019
Document type:
Article