A systematic review and meta-analysis of the prevalence of toxoplasmosis in hemodialysis patients in Iran / 한국역학회지
Epidemiology and Health
; : 2018016-2018.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-786857
Responsible library:
WPRO
ABSTRACT
OBJECTIVES:
Toxoplasmosis is a parasitic disease that occurs worldwide, with a wide range of complications in immunocompromised patients. This systematic review and meta-analysis was performed to evaluate the seroprevalence of Toxoplasma gondii among patients undergoing hemodialysis in Iran.METHODS:
We searched English and Persian databases for studies reporting T. gondii seroprevalence in Iranian hemodialysis patients through December 31, 2017. Inclusion and exclusion criteria were applied.RESULTS:
A total of 10 studies containing 1,865 participants (1,048 patients and 817 controls) met the eligibility criteria. ImmunoglobulinG (IgG) antibodies against T. gondii were found in 58% (95% confidence interval [CI], 46 to 70) of hemodialysis patients and 40% (95% CI, 31 to 50) of healthy controls, while immunoglobulin M (IgM) antibodies were found in 2% (95% CI, 0 to 6) of hemodialysis patients and 0% (95% CI, 0 to 1) of healthy controls. The meta-analysis showed that hemodialysis patients were significantly more likely to be seropositive for IgG (odds ratio [OR], 2.04; 95% CI, 1.54 to 2.70; p < 0.001) and IgM (OR, 2.53; 95% CI, 1.23 to 5.22; p < 0.001) antibodies against T. gondii infection than healthy individuals.CONCLUSIONS:
The current study revealed a high prevalence of T. gondii infection in hemodialysis patients. Since hemodialysis patients are immunocompromised and T. gondii can cause serious clinical complications, we recommend that periodic screenings for T. gondii infection should be incorporated into the routine clinical care of these patients.
Full text:
Available
Health context:
SDG3 - Health and Well-Being
/
Neglected Diseases
Health problem:
Target 3.3: End transmission of communicable diseases
/
Neglected Diseases
/
Zoonoses
Database:
WPRIM (Western Pacific)
Main subject:
Parasitic Diseases
/
Toxoplasma
/
Immunoglobulin G
/
Immunoglobulin M
/
Seroepidemiologic Studies
/
Toxoplasmosis
/
Mass Screening
/
Prevalence
/
Renal Dialysis
/
Immunocompromised Host
Type of study:
Prevalence study
/
Prognostic study
/
Risk factors
/
Screening study
/
Systematic review
Limits:
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Epidemiology and Health
Year:
2018
Document type:
Article