Reversible Metronidazole-induced Encephalopathy in a Patient with Acute Lymphoblastic Leukemia during Chemotherapy / 임상소아혈액종양
Clinical Pediatric Hematology-Oncology
; : 153-156, 2017.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-788604
Responsible library:
WPRO
ABSTRACT
We describe our experience regarding metronidazole-induced encephalopathy in a patient with acute lymphoblastic leukemia during chemotherapy. A 17-year-old girl was admitted to our institution with complaints of abdominal pain and mucoid stools. She was diagnosed with acute lymphoblastic leukemia and had been undergoing intensified chemotherapy protocol. During the fifth week of interim maintenance-1 therapy, she developed a fever and complained of chills. On stool examination, stool occult blood was positive and Clostridium difficile toxin A/B test was positive. She was started on metronidazole treatment for possible Clostridium difficile infection and other inflammatory gastrointestinal diseases. Ten days later, the patient complained of dizziness and nausea. A brain MRI was performed to make a differential diagnosis of any chemotherapy- induced CNS complication such as necrotizing leukoencephalopathy. The brain MRI showed features of metronidazole-induced encephalopathy. Metronidazole was discontinued and symptoms started to subside four days after. A follow-up brain MRI performed at four weeks showed that lesions of the dentate nucleus had disappeared.
Full text:
Available
Health context:
Neglected Diseases
Health problem:
Diarrhea
Database:
WPRIM (Western Pacific)
Main subject:
Brain
/
Brain Diseases
/
Magnetic Resonance Imaging
/
Abdominal Pain
/
Cerebellar Nuclei
/
Follow-Up Studies
/
Clostridioides difficile
/
Chills
/
Diagnosis, Differential
/
Dizziness
Type of study:
Diagnostic study
/
Practice guideline
/
Observational study
/
Prognostic study
Limits:
Adolescent
/
Female
/
Humans
Language:
English
Journal:
Clinical Pediatric Hematology-Oncology
Year:
2017
Document type:
Article