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Stability of tramadol hydrochloride with fentanyl citrate in 0 .9%sodium chloride injection / 药学实践杂志
Article in Zh | WPRIM | ID: wpr-790357
Responsible library: WPRO
ABSTRACT
Objective To study the stability of tramadol hydrochloride with fentanyl citrate in 0.9%sodium chloride injection. Methods The changes in appearance and pH value of the mixture of the two injections in 0.9%sodium chloride injection within 72 hours at ambient temperature were observed .The concentrations of the two drugs were determined by HPLC .The chromatographic separation was achieved on SinoChrom ODS-BP column, and the mobile phase consisted of acetonitrile:0.05 mol/L potassium dihydrogen phosphate (25:75) at a flow rate of 1.0 ml/min..Results No significant differences were found in the pH value and appearance of the solution . The contents of tramadol hydrochloride and fentanyl citrate were high than 98%within 72 hours.Conclusion The mixture of tramadol hydrochloride with fentanyl citrate in 0.9%sodium chloride injection was stability within 72 hours under room temperature .
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Full text: 1 Database: WPRIM Language: Zh Journal: Journal of Pharmaceutical Practice Year: 2014 Document type: Article
Full text: 1 Database: WPRIM Language: Zh Journal: Journal of Pharmaceutical Practice Year: 2014 Document type: Article