Research progress of the structure and function of untranslated regions of enterovirus 71 genome / 中华实验和临床病毒学杂志

ABSTRACT

Enterovirus 71 (EV71) is one of the important pathogens of hand, foot and mouth disease (HFMD) in infants and young children. It is also a very important and common virus after poliovirus which is associated with severe acute neurological disease. Mutations or spatial structure changes in untranslated regions (UTRs) may affect the ability of the virus to translate and replicate, as well as the affinity of the virus for cellular tissue, and even lead to changes in virulence. At present, the pathogenic mechanism of EV71 is still unknown, and the study of untranslated regions is an indispensable part. Here we briefly review the development of the study of basic structure and function of EV71 untranslated regions in recent years.