Plasma Exchange in a Patient with Antineutrophil Cytoplasmic Antibody-associated Vasculitis / 대한수혈학회지
Korean Journal of Blood Transfusion
; : 254-259, 2007.
Article
in Ko
| WPRIM
| ID: wpr-80664
Responsible library:
WPRO
ABSTRACT
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is a systemic autoimmune disease with a poor prognosis in untreated patients, and combination therapy with steroidsand cyclophosphamide is the current standard treatment. Treatment with immunosuppressive agents results in high remission rates; however, there is a considerable morbidity related to the immunosuppressive state, such as life-threatening infections. To reduce serious immunosuppressant-related adverse effects, potentially promising treatment options, including plasma exchange, cytapheresis, administration of intravenous immunoglobulin and TNF-alpha blocking agents have been developed. We performed plasma exchange with steroid pulse therapy for a 52 year-old female patient with pulmonary hemorrhagewith ANCA-associated crescentic glomerulonephritis. After combination therapy, the pulmonary hemorrhage and renal function recovered and myeloperoxidase (MPO)-ANCA decreased.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Plasma
/
Plasma Exchange
/
Prognosis
/
Autoimmune Diseases
/
Vasculitis
/
Immunoglobulins
/
Cytapheresis
/
Tumor Necrosis Factor-alpha
/
Peroxidase
/
Antibodies, Antineutrophil Cytoplasmic
Type of study:
Prognostic_studies
Limits:
Female
/
Humans
Language:
Ko
Journal:
Korean Journal of Blood Transfusion
Year:
2007
Document type:
Article