New diterpenoids isolated from Leonurus japonicus and their acetylcholinesterase inhibitory activity / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 860-864, 2017.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-812048
Responsible library:
WPRO
ABSTRACT
Three new labdane diterpenoids, leojaponicone A (1), isoleojaponicone A (2) and methylisoleojaponicone A (3), were isolated from the herb of Leonurus japonicus. The chemical structures of these secondary metabolites were elucidated on the basis of 1D and 2D NMR, including HMQC, and HMBC spectroscopic techniques. All the new compounds were tested in vitro for their acetylcholinesterase and α-glucosidase inhibitory activity. Compounds 1-3 exhibited low inhibitory effects on α-glucosidase with respect to acarbose and exhibited high inhibitory effects on acetylcholinesterase with respect to huperzine A.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Acetylcholinesterase
/
Plant Extracts
/
Magnetic Resonance Spectroscopy
/
Molecular Structure
/
Chemistry
/
Cholinesterase Inhibitors
/
Leonurus
/
Diterpenes
/
Glycoside Hydrolase Inhibitors
Language:
English
Journal:
Chinese Journal of Natural Medicines (English Ed.)
Year:
2017
Document type:
Article